Year: 2014 | Month: December | Volume 2 | Issue 3
Angiotensin receptors: their pharmacological aspects and side effects vis-à-vis receptor blocker drugs
DOI:10.5958/2321-7111.2014.00012.2
Abstract:
Receptors are the protein molecules embedded in plasma membrane, cytoplasm or nucleus. Receptors received its chemical signals originating from the cells. Through binding to receptors these signals directed cell to produce its action. There are different psychological actions produced by Angiotensin-II such as increase in extracellular volume, peripheral vascular resistance and blood pressure. It is also involved in regulation of cell growth and differentiation. Angiotensin-II Receptor is of two types, AT-I and AT-II. Most of the functions of angiotensin-II are regulated by AT-I. Physiological role of AT-II are not known. Various vital organs of the body like Heart, lungs, kidney, adrenal cortex and brain are rich in AT-I Receptor. Those drugs which block the action of AT-1 on blood vessels and Heart are called as Angiotensin Receptor Blocker (ARBs). There are different ARBs available in the market which are well tolerated and having fewer side effects. ARBs biding affinity towards the receptors is like as condensatran > ibesartan> valsartan> telmisartan> tasosartan> losartan >eprosartan. The main severe side effect shows by ARBs is swelling of tissues, liver and kidney failure, allergic reactions
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